The research proposal foresees the development of new molecular entities based on synthetic peptides and peptidomimetics able to target with high affinity and selectivity receptor and functional sites in the Herpes simplex virus type 1 (HSV-1) lipoproteins, to be used as antiviral compounds in treatment of HSV-1 infections and as tolls to understand the molecular mechanisms of HSV-1 entry. In particular the novel molecules will be developed to target lipoprotein H (go), B (gab), D (god)and L (gel) functional domains of the HSV-1 in order to reduce or abolish virus infectivity. The research goal will be reached through design, synthesis and in vitro and vivo testing of the new molecules.
Funding SchemeEAW - Exploratory awards
KT6 6LG Surbiton