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Diagnoses, pathogeneses and epidemiologies of salmonid alphavirus diseases (SPD/SD DIAGNOSIS)

Objective

Salmon pancreas disease (SPD) and sleeping disease (SD) are emerging diseases of farmed salmon fish, that are caused by closely related, recently characterised alpha viruses. Due to the lack of diagnostics, the prevalence’s of these diseases are unknown but each is thought to be greatly under diagnosed. The primary aim of this project is to develop sensitive, specific, and easy-to-use diagnostic tests for SPD and SD. The project exploits recently acquired knowledge concerning the molecular characterisation of the viruses, to enable the production of improved reagents with which tests for detecting viral antigens and RNA in tissue samples, and virus-specific antibodies in fish sera, can be developed. Sensitive immunohistochemical and in site hybridisation methods will be used to improve the understanding of the pathogeneses of these diseases. Epidemiological aspects will also be studied by investigating the prevalence of infection using serological surveys of salmon and marine fish, by investigating the genetic diversity of virus isolates detected byre -PCR, and by investigating possible sources of infection.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE QUEEN'S UNIVERSITY OF BELFAST
Address
Stoney Road , Stormont
BT4 3SD Belfast
United Kingdom

Participants (4)

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS
France
Address
Technopole Brest-iroise
29280 Plouzane
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
Domaine De Vilvert
78352 Jouy-en-josas
INTERVET NORBIO AS
Norway
Address
Thormoehlensgate 55
5008 Bergen
NORWEGIAN SCHOOL OF VETERINARY SCIENCE
Norway
Address
Ullevaalsveien 72
0033 Oslo