Objective
Rates of chronic infection with hepatitis C virus are high, and this will be a major cause of serious liver diseases such as cirrhosis and hepatocellular carcinoma. Current therapy is ineffective with a failure rate of between 60-80%. The surface envelope lipoproteins Eland E2 of HCV facilitate entry into cells. There is evidence that interaction with cell receptors might also have an adverse effect on normal cell function. Clearly, novel antiviral compounds capable of inhibiting lipoprotein assembly and interaction with cell receptors would have significant therapeutic potential. Therefore, the aims of this project are to:
I.) Perform structural analyses of E1 and E2 to identify conserved regions involved in lipoprotein assembly and receptor interaction;
ii.) Delineate the interaction between host and pathogen at the lipoprotein level;
iii.) Use this intonation to identify new targets for antiviral therapy, and
iv.) Develop cell binding and entry assays for screening future potential antiviral compounds.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses hepatitis C
- medical and health sciences clinical medicine hepatology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NG7 2UH NOTTINGHAM
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.