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Structural and functional studies of hepatitis c virus glycoproteins: identification of targets for antiviral therapy (ENHCV)

Objective

Rates of chronic infection with hepatitis C virus are high, and this will be a major cause of serious liver diseases such as cirrhosis and hepatocellular carcinoma. Current therapy is ineffective with a failure rate of between 60-80%. The surface envelope lipoproteins Eland E2 of HCV facilitate entry into cells. There is evidence that interaction with cell receptors might also have an adverse effect on normal cell function. Clearly, novel antiviral compounds capable of inhibiting lipoprotein assembly and interaction with cell receptors would have significant therapeutic potential. Therefore, the aims of this project are to:
I.) Perform structural analyses of E1 and E2 to identify conserved regions involved in lipoprotein assembly and receptor interaction;
ii.) Delineate the interaction between host and pathogen at the lipoprotein level;
iii.) Use this intonation to identify new targets for antiviral therapy, and
iv.) Develop cell binding and entry assays for screening future potential antiviral compounds.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF NOTTINGHAM
Address
Queen's Medical Centre
NG7 2UH Nottingham
United Kingdom

Participants (8)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Avenue De La Terrasse 14
91198 Gif-sur-yvette
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Du Professeur Calmette 1
59021 Lille
EDWARD JENNER INSTITUTE FOR VACCINE RESEARCH
United Kingdom
Address
High Street, Compton
RG20 7NN Newbury
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE "P. ANGELETTI" SPA
Italy
Address
Via Pontina Km.30,6
00040 Pomezia
JUSTUS-LIEBIG-UNIVERSITY OF GIESSEN
Germany
Address
Frankfurterstrasse 107
35392 Giessen
KAROLINSKA INSTITUTE
Sweden
Address
Karolinska Hospital
17 176 Solna
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Church Street
G11 5JR Glasgow
UNIVERSITY OF GDANSK
Poland
Address
24,Kladki 24
80 822 Gdansk