Objective Vaccines eliciting T cell immunity are likely to be important for protection against diseases such as infection by HIV, HCV or malaria parasites. Current concepts of peptide or protein fragment vaccination do not consider intracellular antigen processing in epitome selection and design of poly-epitome strings. We propose to study proteolysis by immune- and housekeeping protease, and bylysosomal proteases, so as to identify novel epitomes by an enhanced "reverse immunology" approach, to determine distinct epitome sets suitable for preventive and therapeutic vaccines, and to design linkers for optimal intracellular epitoperelease and transport. T cell vaccines for HIV, HCV and malaria will be designed and tested with healthy donor or patient lymphocytes and in a marine malaria model. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health scienceshealth sciencesinfectious diseasesRNA viruseshepatitis Cmedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Address 161,rue de sfvres 161 75743 Paris France See on map EU contribution € 0,00 Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all FOUNDATION "ANDREA CESALPINO" Italy EU contribution € 0,00 Address Viale del policlinico 155 00161 Roma See on map M-SCAN LTD. United Kingdom EU contribution € 0,00 Address Silwood park, sunninghill SL5 7PZ Ascot See on map MRC National Institute for Medical Research United Kingdom EU contribution € 0,00 Address The ridgeway mill hil NW7 1AA London See on map
