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Contenuto archiviato il 2024-05-27

Development of prophylactic and therapeutic vaccines optimised for cellular processing and presentation to t lymphocytes and targeted to professional antigen presenting cells (protarvac)

Obiettivo

Vaccines eliciting T cell immunity are likely to be important for protection against diseases such as infection by HIV, HCV or malaria parasites. Current concepts of peptide or protein fragment vaccination do not consider intracellular antigen processing in epitome selection and design of poly-epitome strings. We propose to study proteolysis by immune- and housekeeping protease, and bylysosomal proteases, so as to identify novel epitomes by an enhanced "reverse immunology" approach, to determine distinct epitome sets suitable for preventive and therapeutic vaccines, and to design linkers for optimal intracellular epitoperelease and transport. T cell vaccines for HIV, HCV and malaria will be designed and tested with healthy donor or patient lymphocytes and in a marine malaria model.

Invito a presentare proposte

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Meccanismo di finanziamento

CSC - Cost-sharing contracts

Coordinatore

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Contributo UE
Nessun dato
Indirizzo
161,Rue de SFvres 161
75743 PARIS
Francia

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Costo totale
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Partecipanti (3)