Objective Classical swine fever virus (CSFV) is a well-suited model for the evaluation of protective immunity in swine induced by virus subunits. Novel vaccines, which are investigated in this project, can be divided into two groups, 1. Viral subunit antigens generated in vitro and 2. DNA- or RNA-based delivery systems and a Para poxvirus-based expression system, producing the relevant antigens in vivo. In addition the modification of such vaccines with potent immuno-modulatorymolecules and loading of dendrite cells (DC) will be tested for improving stimulatory-stimulatory effects in swine. Since only highly efficacious vaccines are responsible for a rapid onset of protection in naive animal populations this study will focus on the immune response after primary vaccination. The results of the study will provide sufficient information to be able to identify efficient vaccine-types against CSFV as well as other emerging diseases. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH Address Paul ehrlichstr. 28 72076 Tuebingen Germany See on map EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS France EU contribution € 0,00 Address 22440 Ploufragan See on map FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW Belgium EU contribution € 0,00 Address 65,paardenstraat 65 vub 1640 Rhode-st-genese See on map INSTITUTE OF VIROLOGY AND IMMUNOPROPHYLAXIS Switzerland EU contribution € 0,00 Address Sensemattstrasse 293 3147 Mittelhauesern See on map THE QUEEN'S UNIVERSITY OF BELFAST United Kingdom EU contribution € 0,00 Address Stoney road , stormont BT4 3SD Belfast See on map THE UNIVERSITY OF TUEBINGEN Germany EU contribution € 0,00 Address Auf der morgenstelle 18 72076 Tuebingen See on map UNIVERSITY OF VETERINARY MEDICINE VIENNA Austria EU contribution € 0,00 Address Veterinaerplatz 1 1210 Wien See on map
