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Identification of efficacious delivery systems for recombinant and nucleic acid construct vaccines (EFFICACIOUS DELIVERY)

Objective

Classical swine fever virus (CSFV) is a well-suited model for the evaluation of protective immunity in swine induced by virus subunits. Novel vaccines, which are investigated in this project, can be divided into two groups, 1. Viral subunit antigens generated in vitro and 2. DNA- or RNA-based delivery systems and a Para poxvirus-based expression system, producing the relevant antigens in vivo. In addition the modification of such vaccines with potent immuno-modulatorymolecules and loading of dendrite cells (DC) will be tested for improving stimulatory-stimulatory effects in swine. Since only highly efficacious vaccines are responsible for a rapid onset of protection in naive animal populations this study will focus on the immune response after primary vaccination. The results of the study will provide sufficient information to be able to identify efficient vaccine-types against CSFV as well as other emerging diseases.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH
Address
Paul Ehrlichstr. 28
72076 Tuebingen
Germany

Participants (6)

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS
France
Address

22440 Ploufragan
FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW
Belgium
Address
65,Paardenstraat 65 Vub
1640 Rhode-st-genese
INSTITUTE OF VIROLOGY AND IMMUNOPROPHYLAXIS
Switzerland
Address
Sensemattstrasse 293
3147 Mittelhauesern
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
Address
Stoney Road , Stormont
BT4 3SD Belfast
THE UNIVERSITY OF TUEBINGEN
Germany
Address
Auf Der Morgenstelle 18
72076 Tuebingen
UNIVERSITY OF VETERINARY MEDICINE VIENNA
Austria
Address
Veterinaerplatz 1
1210 Wien