Immunological mechanisms of protection against classical swine fever virus: towards the development of new efficacious marker vaccines

Objective

The high costs of a Classical Swine Fever (CSF) -outbreak, the social impact and resistance against destruction of pigs have led to reconsideration of emergency vaccination against CSF. The application of marker vaccines that can provide early protection might contribute to improved intervention and control strategies and might limit the duration and costs of an outbreak. The objective of this project is to understand the immune mechanisms underlying protection against CSF, in particular the mechanisms involved in early protection against clinical signs of CSF and in the reduction of (horizontal) virus transmission. The knowledge about relevant viral components, and about the quality of the vaccine-induced immune response may contribute to the future development of new and safe marker vaccines that can induce a fast protective immune response.

Fields of science

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › basic medicine › immunology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

ID LELYSTAD - INSTITUTE FOR ANIMAL HEALTH AND SCIENCE

Address

Edelhertweg 15
8200 AB Lelystad
Netherlands

Participants (3)

FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH

Germany

Address

Paul Ehrlichstr. 28
72076 Tuebingen

INSTITUTE FOR ANIMAL HEALTH

United Kingdom

Address

Ash Road, Nr Woking
GU24 0NF Woking

INSTITUTE OF VIROLOGY AND IMMUNOPROPHYLAXIS

Switzerland

Address

Sensemattstrasse 293
3147 Mittelhauesern