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Content archived on 2024-05-27

Creutzfeldt-Jakob disease: epidemiology, risk factors, diagnostic tests and genetics

Objective

There is compelling evidence that the same agent is responsible for variant CJD (vCJD) and bovine spongiform encephalopathy. Cases of vCJD have been identified in the UK, France and the Republic of Ireland. It is not possible to predict the numbers of cases that may occur in European countries. It is essential to monitor this disease and to identify relevant risk factors for vCJD. In order to achieve this, it is necessary to identify all forms of CJD, including atypical phenotypes of sporadic CJD (sCJD). Prion protein (PrP) genotype is an important determinant of disease susceptibility and phenotype. Detailed population studies of PrP genotype are necessary in order to address issues of age and gender distributions of CJD within a given region and issues of differing incidence between regions. This proposal addresses these objectives through the co-ordination and harmonization.

Call for proposal

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Coordinator

STATENS SERUM INSTITUT
EU contribution
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Address
5,Artillerivej 5
2300 KOEPENHAGEN
Denmark

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Participants (11)