Intermodular transfer in antibiotic mixed polyketide-peptide synthetases

Objective

Polypeptides and non-ribosomal encoded polypeptides are a rich natural source of antibiotics. Hybrid multienzymes will be engineered containing modules drawn from both PKS and NRPS, and the products characterised. It is aimed both to uncover the rules for productive linking of PKS and NRPS modules and to apply these rules to produce novel and potentially useful peptide-polypeptides.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antibiotics

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Address

80,tennis Court Road, 80
CB2 1GA Cambridge
United Kingdom

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