Objective Lentivirus vaccines have proven difficult to develop to date. The reasons for this include a lack of information on target antigens, protective immune responses, and effective vaccine strategies. We propose to evaluate DNA vaccination strategies in sheep challenged with maedi visna virus (MVV). Sheep will be immunised with MVV core or envelope genes or a combination of these via the skin (by gene gun) or mucosal tissues (using Salmonella vehicles). The effects of including genes encoding IFNg or IL4 during priming will also be investigated. Animals will be boosted with recombinant Adenovirus encoding the MVV genes. Immunological variables as well as virus load and disease will be determined before and after challenge. The project will help to identify protective virus antigens, provide useful information on immune correlates of protection, and indicate whether mucosal or cutaneous immunisation correlates with protection. Fields of science medical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF EDINBURGH Address Summerhall EH9 1QH Edinburgh United Kingdom See on map EU contribution € 0,00 Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS France EU contribution € 0,00 Address Routes des chappes, 105 06902 Sophia antipolis See on map CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution € 0,00 Address 27 bd jean moulin 13385 Marseille See on map CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 0,00 Address Calle serrano 117 28006 Madrid See on map UNIVERSIDAD DE ZARAGOZA Spain EU contribution € 0,00 Address Miguel servet 177 50013 Zaragoza See on map UNIVERSITA DEGLI STUDI DI PISA Italy EU contribution € 0,00 Address Via delle piagge 2 56124 Pisa See on map UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II France EU contribution € 0,00 Address Boulevard jean moulin 27 13385 Marseille See on map UNIVERSITY OF ICELAND Iceland EU contribution € 0,00 Address Keldur v/vesturlandsveg 112 Reykjavik See on map UNIVERSITY OF TORINO Italy EU contribution € 0,00 Address Via nizza 52 10126 Torino (turin) See on map University of Cambridge United Kingdom EU contribution € 0,00 Address Madingley road CB3 0ES Cambridge See on map
