Evaluation of lentivirus dna vaccination strategies in sheep

Cel

Lentivirus vaccines have proven difficult to develop to date. The reasons for this include a lack of information on target antigens, protective immune responses, and effective vaccine strategies. We propose to evaluate DNA vaccination strategies in sheep challenged with maedi visna virus (MVV). Sheep will be immunised with MVV core or envelope genes or a combination of these via the skin (by gene gun) or mucosal tissues (using Salmonella vehicles). The effects of including genes encoding IFNg or IL4 during priming will also be investigated. Animals will be boosted with recombinant Adenovirus encoding the MVV genes. Immunological variables as well as virus load and disease will be determined before and after challenge. The project will help to identify protective virus antigens, provide useful information on immune correlates of protection, and indicate whether mucosal or cutaneous immunisation correlates with protection.

Dziedzina nauki

• medycyna i nauki o zdrowiu › medycyna kliniczna › immunologia › szczepienie
• nauki przyrodnicze › nauki biologiczne › mikrobiologia › wirusologia
• nauki przyrodnicze › nauki biologiczne › genetyka › DNA
• medycyna i nauki o zdrowiu › medycyna kliniczna › farmakologia i farmacja › lek › szczepionki

Program(-y)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Temat(-y)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Zaproszenie do składania wniosków

Data not available

System finansowania

CSC - Cost-sharing contracts

Koordynator

UNIVERSITY OF EDINBURGH

Adres

Summerhall
EH9 1QH Edinburgh
United Kingdom

Uczestnicy (9)

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS

Francja

Adres

Routes Des Chappes, 105
06902 Sophia Antipolis

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Francja

Adres

27 Bd Jean Moulin
13385 Marseille

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Hiszpania

Adres

Calle Serrano 117
28006 Madrid

UNIVERSIDAD DE ZARAGOZA

Hiszpania

Adres

Miguel Servet 177
50013 Zaragoza

UNIVERSITA DEGLI STUDI DI PISA

Włochy

Adres

Via Delle Piagge 2
56124 Pisa

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

Francja

Adres

Boulevard Jean Moulin 27
13385 Marseille

UNIVERSITY OF ICELAND

Islandia

Adres

Keldur V/vesturlandsveg
112 Reykjavik

UNIVERSITY OF TORINO

Włochy

Adres

Via Nizza 52
10126 Torino (Turin)

University of Cambridge

United Kingdom

Adres

Madingley Road
CB3 0ES Cambridge