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Evaluation of lentivirus dna vaccination strategies in sheep

Cel

Lentivirus vaccines have proven difficult to develop to date. The reasons for this include a lack of information on target antigens, protective immune responses, and effective vaccine strategies. We propose to evaluate DNA vaccination strategies in sheep challenged with maedi visna virus (MVV). Sheep will be immunised with MVV core or envelope genes or a combination of these via the skin (by gene gun) or mucosal tissues (using Salmonella vehicles). The effects of including genes encoding IFNg or IL4 during priming will also be investigated. Animals will be boosted with recombinant Adenovirus encoding the MVV genes. Immunological variables as well as virus load and disease will be determined before and after challenge. The project will help to identify protective virus antigens, provide useful information on immune correlates of protection, and indicate whether mucosal or cutaneous immunisation correlates with protection.

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Koordynator

UNIVERSITY OF EDINBURGH
Adres
Summerhall
EH9 1QH Edinburgh
United Kingdom

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Uczestnicy (9)

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS
Francja
Adres
Routes Des Chappes, 105
06902 Sophia Antipolis

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Francja
Adres
27 Bd Jean Moulin
13385 Marseille

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CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Hiszpania
Adres
Calle Serrano 117
28006 Madrid

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UNIVERSIDAD DE ZARAGOZA
Hiszpania
Adres
Miguel Servet 177
50013 Zaragoza

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UNIVERSITA DEGLI STUDI DI PISA
Włochy
Adres
Via Delle Piagge 2
56124 Pisa

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UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II
Francja
Adres
Boulevard Jean Moulin 27
13385 Marseille

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UNIVERSITY OF ICELAND
Islandia
Adres
Keldur V/vesturlandsveg
112 Reykjavik

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UNIVERSITY OF TORINO
Włochy
Adres
Via Nizza 52
10126 Torino (Turin)

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University of Cambridge
United Kingdom
Adres
Madingley Road
CB3 0ES Cambridge

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