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Antimicrobial resistance transfer from and between gram-positive bacteria of the digestive tract and consequences for virulence (ARTRADI)

Objective

Horizontal gene transfer is one of the main mechanisms facilitating the spread of antibiotic resistance. There is a gap in our knowledge of the extent and rate of prokaryotic gene flux as well as barriers for the expression and maintenance of transferred genes in new hosts. This project will focus on the transfer of glycopeptides, microcline, and tetracycline resistance determinants between Gram-positive bacteria from digestive tract samples from animals and human and food. The study in vitro and in vivo of:
(I) the transferability and the stability of resistance determinants;
(ii) the link of resistance with virulence;
(iii) the detection and characterisation of new resistance determinants;
(iv) the ability of food-ingested bacteria to pick up and retransfer resistance determinants will further our knowledge as to how to control the spread of resistance and virulence markers.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITE DE PARIS-SUD XI
Address
Rue Jean-baptiste Clément 5
92296 Chatenay Malabry
France

Participants (7)

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
Domaine De Vilvert, Bètiment 440
78352 Jouy-en-josas
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
00161 Roma
ROWETT RESEARCH INSTITUTE
United Kingdom
Address
Greenburn Road
AB21 9SB Aberdeen
TECHNICAL RESEARCH CENTRE OF FINLAND
Finland
Address
Tietotie 2
02044 Espoo
UNIVERSITA POLITECNICA DELLE MARCHE
Italy
Address
Via Ranieri-monte D'ago
60131 Ancona
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gray's Inn Road 25
WC1X 8LD London
UNIVERSITY OF TROMSOE
Norway
Address
Breivika
9001 Tromsoe