Horizontal gene transfer is one of the main mechanisms facilitating the spread of antibiotic resistance. There is a gap in our knowledge of the extent and rate of prokaryotic gene flux as well as barriers for the expression and maintenance of transferred genes in new hosts. This project will focus on the transfer of glycopeptides, microcline, and tetracycline resistance determinants between Gram-positive bacteria from digestive tract samples from animals and human and food. The study in vitro and in vivo of:
(I) the transferability and the stability of resistance determinants;
(ii) the link of resistance with virulence;
(iii) the detection and characterisation of new resistance determinants;
(iv) the ability of food-ingested bacteria to pick up and retransfer resistance determinants will further our knowledge as to how to control the spread of resistance and virulence markers.
Funding SchemeCSC - Cost-sharing contracts
AB21 9SB Aberdeen
WC1X 8LD London