Antimicrobial resistance transfer from and between gram-positive bacteria of the digestive tract and consequences for virulence (ARTRADI)

Objective

Horizontal gene transfer is one of the main mechanisms facilitating the spread of antibiotic resistance. There is a gap in our knowledge of the extent and rate of prokaryotic gene flux as well as barriers for the expression and maintenance of transferred genes in new hosts. This project will focus on the transfer of glycopeptides, microcline, and tetracycline resistance determinants between Gram-positive bacteria from digestive tract samples from animals and human and food. The study in vitro and in vivo of:
(I) the transferability and the stability of resistance determinants;
(ii) the link of resistance with virulence;
(iii) the detection and characterisation of new resistance determinants;
(iv) the ability of food-ingested bacteria to pick up and retransfer resistance determinants will further our knowledge as to how to control the spread of resistance and virulence markers.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITE DE PARIS-SUD XI

Address

Rue Jean-baptiste Clément 5
92296 Chatenay Malabry
France

Participants (7)

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

Address

Domaine De Vilvert, Bètiment 440
78352 Jouy-en-josas

ISTITUTO SUPERIORE DI SANITA

Italy

Address

Viale Regina Elena 299
00161 Roma

ROWETT RESEARCH INSTITUTE

United Kingdom

Address

Greenburn Road
AB21 9SB Aberdeen

TECHNICAL RESEARCH CENTRE OF FINLAND

Finland

Address

Tietotie 2
02044 Espoo

UNIVERSITA POLITECNICA DELLE MARCHE

Italy

Address

Via Ranieri-monte D'ago
60131 Ancona

UNIVERSITY COLLEGE LONDON

United Kingdom

Address

Gray's Inn Road 25
WC1X 8LD London

UNIVERSITY OF TROMSOE

Norway

Address

Breivika
9001 Tromsoe