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Mucosal vaccines against human and simian immunodeficiency viruses based on dendritic cells (MUVADEN)

Objective

There is urgent need for HIV vaccines with high protective efficacy, low cost and simple immunisation schedule. Aim of this project is to assess in the macaque model the efficacy of
(I) new vaccine candidates (lipid-DNA; single cycle lent viral vector; recombinant S.gordonii) made by our consortium;
(ii) prime-boost vaccination strategies with/without adjuvant (GM-CSF, TNF-alpha, Cog motifs) and
(iii) route of vaccine application (via the tonsils vs. potential) for inducing immunity and protect ion to mussel challenge. We also address to vaccine biology at dendrite cell level. With the oral route we target dendrite cells that are numerous at this site and mature them with adjuvant. Thus, we expect to see an enhanced immunity, a low viral set point (undetectable virus by infectious unit and RNA assays) or at least a reduction of viral load (100 RNA copies/ml of plasma), clinical well-being and normal CD4 counts and function.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

BERNHARD NOCHT INSTITUT FUER TROPENMEDIZIN
Address
Bernhard-nocht-strasse 74
20359 Hamburg
Germany

Participants (9)

DEUTSCHES PRIMATENZENTRUM GMBH
Germany
Address
4,Kellnerweg 4
37077 Göttingen
FREIE UNIVERSITAET BERLIN
Germany
Address
Hindenburgdamm 27-18
12203 Berlin
INSTITUTE FOR RESEARCH IN BIOMEDICINE
Switzerland
Address
Via Vincenzo Vela 6
CH-6500 Bellinzona
LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK
Austria
Address
Fritz-pregl-strasse 3
6010 Innsbruck
RUHR-UNIVERSITY BOCHUM
Germany
Address
Universitaetsstrasse 150
44780 Bochum
THE ROCKEFELLER UNIVERSITY
United States
Address
York Avenue 1230
10021 New York
UNIVERSIT DEGLI STUDI DI SIENA
Italy
Address
Via Bracci, 16
53100 Siena
UNIVERSITY OF ICELAND
Iceland
Address
Keldur V/vesturlandsveg
112 Reykjavik
UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
Viale Regina Elena 324
00161 Roma