Objective
There is urgent need for HIV vaccines with high protective efficacy, low cost and simple immunisation schedule. Aim of this project is to assess in the macaque model the efficacy of
(I) new vaccine candidates (lipid-DNA; single cycle lent viral vector; recombinant S.gordonii) made by our consortium;
(ii) prime-boost vaccination strategies with/without adjuvant (GM-CSF, TNF-alpha, Cog motifs) and
(iii) route of vaccine application (via the tonsils vs. potential) for inducing immunity and protect ion to mussel challenge. We also address to vaccine biology at dendrite cell level. With the oral route we target dendrite cells that are numerous at this site and mature them with adjuvant. Thus, we expect to see an enhanced immunity, a low viral set point (undetectable virus by infectious unit and RNA assays) or at least a reduction of viral load (100 RNA copies/ml of plasma), clinical well-being and normal CD4 counts and function.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciencesbasic medicineimmunologyimmunisation
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- natural sciencesbiological sciencesgeneticsRNA
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
20359 HAMBURG
Germany