Mucosal vaccines against human and simian immunodeficiency viruses based on dendritic cells (MUVADEN)

Objective

There is urgent need for HIV vaccines with high protective efficacy, low cost and simple immunisation schedule. Aim of this project is to assess in the macaque model the efficacy of
(I) new vaccine candidates (lipid-DNA; single cycle lent viral vector; recombinant S.gordonii) made by our consortium;
(ii) prime-boost vaccination strategies with/without adjuvant (GM-CSF, TNF-alpha, Cog motifs) and
(iii) route of vaccine application (via the tonsils vs. potential) for inducing immunity and protect ion to mussel challenge. We also address to vaccine biology at dendrite cell level. With the oral route we target dendrite cells that are numerous at this site and mature them with adjuvant. Thus, we expect to see an enhanced immunity, a low viral set point (undetectable virus by infectious unit and RNA assays) or at least a reduction of viral load (100 RNA copies/ml of plasma), clinical well-being and normal CD4 counts and function.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

BERNHARD NOCHT INSTITUT FUER TROPENMEDIZIN

Address

Bernhard-nocht-strasse 74
20359 Hamburg
Germany

Participants (9)

DEUTSCHES PRIMATENZENTRUM GMBH

Germany

Address

4,Kellnerweg 4
37077 Göttingen

FREIE UNIVERSITAET BERLIN

Germany

Address

Hindenburgdamm 27-18
12203 Berlin

INSTITUTE FOR RESEARCH IN BIOMEDICINE

Switzerland

Address

Via Vincenzo Vela 6
CH-6500 Bellinzona

LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK

Austria

Address

Fritz-pregl-strasse 3
6010 Innsbruck

RUHR-UNIVERSITY BOCHUM

Germany

Address

Universitaetsstrasse 150
44780 Bochum

THE ROCKEFELLER UNIVERSITY

United States

Address

York Avenue 1230
10021 New York

UNIVERSIT DEGLI STUDI DI SIENA

Italy

Address

Via Bracci, 16
53100 Siena

UNIVERSITY OF ICELAND

Iceland

Address

Keldur V/vesturlandsveg
112 Reykjavik

UNIVERSITY OF ROME "LA SAPIENZA"

Italy

Address

Viale Regina Elena 324
00161 Roma