Targeting immunocomplex production in plants (TIPP)

Objective

The goal of this project is the development of generic systems for oral immunisation. Immunocornplexes will be designed which will consist of an enteric targeting molecule fused to the antigen of interest. The targeting molecule will be based on the S protein of Transmissible gastroenteritis corona virus (TGEV), a protein with proven enteric targeting properties. This targeting molecule will be a generic vehicle for the oral immunisation of pigs, and the first application will be focused on Porcine circovirus (PCV). Subsequently other antigens will be expressed. The production of the high levels of the immunocomplexes required for oral immunisation will be achieved through the use of novel plant expression systems (replicas). The plant-derived immunocomplexes will be assessed for their ability to induce a protective secretary immune response in pigs and their properties compared with the same material expressed in mammalian cells.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

JOHN INNES CENTRE

Address

Norwich Research Park, Colney
NR4 7UH Norwich
United Kingdom

Participants (2)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Address

Campus De La Universidad Autonoma De Madrid
28049 Madrid

FORT DODGE VETERINARIA S.A.

Spain

Address

Carretera Camprodon S/n Km 13 Finca "La Riba"
17813 Vall De Bianya