Objective
The goal of this project is the development of generic systems for oral immunisation. Immunocornplexes will be designed which will consist of an enteric targeting molecule fused to the antigen of interest. The targeting molecule will be based on the S protein of Transmissible gastroenteritis corona virus (TGEV), a protein with proven enteric targeting properties. This targeting molecule will be a generic vehicle for the oral immunisation of pigs, and the first application will be focused on Porcine circovirus (PCV). Subsequently other antigens will be expressed. The production of the high levels of the immunocomplexes required for oral immunisation will be achieved through the use of novel plant expression systems (replicas). The plant-derived immunocomplexes will be assessed for their ability to induce a protective secretary immune response in pigs and their properties compared with the same material expressed in mammalian cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciencesbasic medicineimmunologyimmunisation
- natural sciencesbiological sciencesmicrobiologyvirology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
NR4 7UH NORWICH
United Kingdom