Genetic diversity of malaria parasites is a major obstacle to develop rational control strategies against this poverty related disease. Increase of health threatening drug resistance must be monitored and prevented to protect introduced drugs. We propose to evaluate newly developed DNA micro arrays for drug resistance monitoring in affected areas. Results will allow to capture dynamics of drug resistance and to forecast its development by establishing a community based Genetic Resistance Index, providing tools for rational and evidence based decisions on optimal use of drugs. We will assess the relationship between in vivo drug sensitivity and in vitro susceptibility to several anti-malarial and prevalence of multiple Snips providing correlates for clinical resistance. Sequencing will identify additional informative cordons. We will also explore putt as a potential marker for resistance to artemisinin derivatives.
Funding SchemeCSC - Cost-sharing contracts