Objective Genetic diversity of malaria parasites is a major obstacle to develop rational control strategies against this poverty related disease. Increase of health threatening drug resistance must be monitored and prevented to protect introduced drugs. We propose to evaluate newly developed DNA micro arrays for drug resistance monitoring in affected areas. Results will allow to capture dynamics of drug resistance and to forecast its development by establishing a community based Genetic Resistance Index, providing tools for rational and evidence based decisions on optimal use of drugs. We will assess the relationship between in vivo drug sensitivity and in vitro susceptibility to several anti-malarial and prevalence of multiple Snips providing correlates for clinical resistance. Sequencing will identify additional informative cordons. We will also explore putt as a potential marker for resistance to artemisinin derivatives. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineallergologydrug allergymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistance Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSIDADE NOVA DE LISBOA EU contribution No data Address Rua de Junqueira 96 1349 LISBOA Portugal See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT PASTEUR France EU contribution No data Address Rue du Docteur Roux 25 75724 PARIS See on map Total cost No data INSTITUT PASTEUR DE LA GUYANE FRANCAISE France EU contribution No data Address 97306 CAYENNE See on map Total cost No data INSTITUT PASTEUR DE MADAGASCAR Madagascar EU contribution No data Address 101 ANTANANARIVO See on map Total cost No data INSTITUT PASTEUR DU CAMBODGE Cambodia EU contribution No data Address Boulevard Monivong, 5 PHNOM PENH See on map Total cost No data Institut Pasteur de Dakar Senegal EU contribution No data Address 36,Avenue Pasteur 36 30 DAKAR See on map Total cost No data SWISS TROPICAL INSTITUTE Switzerland EU contribution No data Address Socinstrasse 57 4051 BASEL See on map Total cost No data
