Skip to main content

Development of a malaria resistance DNA chip as public health tool for the management of plasmodium falciparum malaria drug resistance

Objective

Genetic diversity of malaria parasites is a major obstacle to develop rational control strategies against this poverty related disease. Increase of health threatening drug resistance must be monitored and prevented to protect introduced drugs. We propose to evaluate newly developed DNA micro arrays for drug resistance monitoring in affected areas. Results will allow to capture dynamics of drug resistance and to forecast its development by establishing a community based Genetic Resistance Index, providing tools for rational and evidence based decisions on optimal use of drugs. We will assess the relationship between in vivo drug sensitivity and in vitro susceptibility to several anti-malarial and prevalence of multiple Snips providing correlates for clinical resistance. Sequencing will identify additional informative cordons. We will also explore putt as a potential marker for resistance to artemisinin derivatives.

Funding Scheme

CSC - Cost-sharing contracts
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSIDADE NOVA DE LISBOA
Address
Rua De Junqueira 96
1349 Lisboa
Portugal

Participants (6)

INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 25
75724 Paris
INSTITUT PASTEUR DE LA GUYANE FRANCAISE
France
Address

97306 Cayenne
INSTITUT PASTEUR DE MADAGASCAR
Madagascar
Address

101 Antananarivo
INSTITUT PASTEUR DU CAMBODGE
Cambodia
Address
Boulevard Monivong, 5
Phnom Penh
Institut Pasteur de Dakar
Senegal
Address
36,Avenue Pasteur 36
30 Dakar
SWISS TROPICAL INSTITUTE
Switzerland
Address
Socinstrasse 57
4051 Basel