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Characterisation of mycobacterium tuberculosis populations during infection: a longitudinal study on drug resistance development

Objective

Drug resistance arises in Mycobacterium tuberculosis (MTB) generally by mutation of chromosomal genes, but despite combined drug therapy the spread of multi-drug- resistant (MDR) strains is alarmingly increasing. The LONG-DRUG project is a longitudinal study, carried out in prisons and the civil society in an area with high MDR-TB prevalence, which aims to document the generation of multi drug resistant MTB strains through the use of novel molecular techniques. The combined use of a variety of techniques on longitudinally obtained samples and primary cultures will enable to generate clinically significant knowledge on the evolution of multi drug resistance in Mycobacterium.

Call for proposal

Data not available

Coordinator

UNIVERSIT DEGLI STUDI DI SIENA
Address
Via Bracci, 16
53100 Siena
Italy

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Participants (8)

EPICENTRE - GROUPE EUROPEEN D'EXPERTISE EN EPIDEMIOLOGIE D'INTERVENTION
France
Address
8,rue Saint Sabin 8
75011 Paris

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ESSAI CLINIQUE EVALUATION EPIDEMIOLOGIE STATISTIQUES
France
Address
Rue A Lancon, 49
75013 Paris

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FONDATION MEDECINS SANS FRONTIERES
France
Address
Rue Saint Sabin 8
75011 Paris

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ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
00161 Roma

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LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH
Germany
Address
5,leopoldstrasse 5
80802 Muenchen

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RESEARCH CENTER BORSTEL, CENTER FOR MEDICINE AND BIOLOGICAL SCIENCE
Germany
Address
18,parkallee 18
23845 Borstel

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UNIVERSITY OF CAGLIARI
Italy
Address
Via Binaghi, 4
09121 Cagliari

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UNIVERSITY OF LEICESTER
United Kingdom
Address
Maurice Shock Building
LE1 9HN Leicester

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