Characterisation of mycobacterium tuberculosis populations during infection: a longitudinal study on drug resistance development

Objective

Drug resistance arises in Mycobacterium tuberculosis (MTB) generally by mutation of chromosomal genes, but despite combined drug therapy the spread of multi-drug- resistant (MDR) strains is alarmingly increasing. The LONG-DRUG project is a longitudinal study, carried out in prisons and the civil society in an area with high MDR-TB prevalence, which aims to document the generation of multi drug resistant MTB strains through the use of novel molecular techniques. The combined use of a variety of techniques on longitudinally obtained samples and primary cultures will enable to generate clinically significant knowledge on the evolution of multi drug resistance in Mycobacterium.

Fields of science

• medical and health sciences › clinical medicine › pneumology › tuberculosis
• natural sciences › biological sciences › genetics › mutation
• social sciences › political sciences › political policies › civil society
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance › multidrug resistance

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSIT DEGLI STUDI DI SIENA

Address

Via Bracci, 16
53100 Siena
Italy

Links

Participants (8)

EPICENTRE - GROUPE EUROPEEN D'EXPERTISE EN EPIDEMIOLOGIE D'INTERVENTION

France

Address

8,rue Saint Sabin 8
75011 Paris

Links

ESSAI CLINIQUE EVALUATION EPIDEMIOLOGIE STATISTIQUES

France

Address

Rue A Lancon, 49
75013 Paris

Links

FONDATION MEDECINS SANS FRONTIERES

France

Address

Rue Saint Sabin 8
75011 Paris

Links

ISTITUTO SUPERIORE DI SANITA

Italy

Address

Viale Regina Elena 299
00161 Roma

Links

LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH

Germany

Address

5,leopoldstrasse 5
80802 Muenchen

Links

RESEARCH CENTER BORSTEL, CENTER FOR MEDICINE AND BIOLOGICAL SCIENCE

Germany

Address

18,parkallee 18
23845 Borstel

Links

UNIVERSITY OF CAGLIARI

Italy

Address

Via Binaghi, 4
09121 Cagliari

Links

UNIVERSITY OF LEICESTER

United Kingdom

Address

Maurice Shock Building
LE1 9HN Leicester

Links