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Characterisation of mycobacterium tuberculosis populations during infection: a longitudinal study on drug resistance development

Objective

Drug resistance arises in Mycobacterium tuberculosis (MTB) generally by mutation of chromosomal genes, but despite combined drug therapy the spread of multi-drug- resistant (MDR) strains is alarmingly increasing. The LONG-DRUG project is a longitudinal study, carried out in prisons and the civil society in an area with high MDR-TB prevalence, which aims to document the generation of multi drug resistant MTB strains through the use of novel molecular techniques. The combined use of a variety of techniques on longitudinally obtained samples and primary cultures will enable to generate clinically significant knowledge on the evolution of multi drug resistance in Mycobacterium.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSIT DEGLI STUDI DI SIENA
Address
Via Bracci, 16
53100 Siena
Italy

Participants (8)

EPICENTRE - GROUPE EUROPEEN D'EXPERTISE EN EPIDEMIOLOGIE D'INTERVENTION
France
Address
8,Rue Saint Sabin 8
75011 Paris
ESSAI CLINIQUE EVALUATION EPIDEMIOLOGIE STATISTIQUES
France
Address
Rue A Lancon, 49
75013 Paris
FONDATION MEDECINS SANS FRONTIERES
France
Address
Rue Saint Sabin 8
75011 Paris
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
00161 Roma
LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH
Germany
Address
5,Leopoldstrasse 5
80802 Muenchen
RESEARCH CENTER BORSTEL, CENTER FOR MEDICINE AND BIOLOGICAL SCIENCE
Germany
Address
18,Parkallee 18
23845 Borstel
UNIVERSITY OF CAGLIARI
Italy
Address
Via Binaghi, 4
09121 Cagliari
UNIVERSITY OF LEICESTER
United Kingdom
Address
Maurice Shock Building
LE1 9HN Leicester