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Characterisation of mycobacterium tuberculosis populations during infection: a longitudinal study on drug resistance development

Objective

Drug resistance arises in Mycobacterium tuberculosis (MTB) generally by mutation of chromosomal genes, but despite combined drug therapy the spread of multi-drug- resistant (MDR) strains is alarmingly increasing. The LONG-DRUG project is a longitudinal study, carried out in prisons and the civil society in an area with high MDR-TB prevalence, which aims to document the generation of multi drug resistant MTB strains through the use of novel molecular techniques. The combined use of a variety of techniques on longitudinally obtained samples and primary cultures will enable to generate clinically significant knowledge on the evolution of multi drug resistance in Mycobacterium.

Call for proposal

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Coordinator

UNIVERSIT DEGLI STUDI DI SIENA
EU contribution
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Address
Via Bracci, 16
53100 SIENA
Italy

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Total cost
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Participants (8)