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Human and animal metapneumovirus molecular and clinical studies for disease control

Objective

A newly discovered virus, human metapneumovirus (hMPV), responsible for respiratory disease in young children, is closely related to subgroup C isolates of the prototype metapneumovirus, avian pneumovirus (APV). APV is a major cause of significant economic losses in the poultry industry in Europe. Current diagnostic techniques cannot detect these metapneumoviruses and as a result the significance and distribution of hMPV subgroup C APV are not known. Thus the burden of disease from these agents cannot be assessed. The proposal addresses these problems by generating new, standardised, detection and characterisation assays, developed for commercial use. Using reverse genetics techniques for both hMPV and APV, the molecular biology, aspects of pathogenicity and host specificity will be analysed This will also generate recombinant viruses which will be the foundation for future rational vaccine design.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF WARWICK
Address
Gibbet Hill Road
Coventry
United Kingdom

Participants (5)

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS
France
Address

22440 Ploufragan
ERASMUS UNIVERSITEIT ROTTERDAM
Netherlands
Address
50,Dr. Molewaterplein 50 Erasmus University Hospital
3015 GE Rotterdam
INMUNOLOGIA Y GENETICA APLICADA SA
Spain
Address
Hermanos Garcia Noblejas 41
Madrid
INSTITUTE OF HEALTH CARLOS III
Spain
Address
Km.2,carretera De Majadahonda - Pozuelo Km.2
28220 Madrid
VIRONOVATIVE BV
Netherlands
Address
Burgemeester Oudlaan, 50
3062 PA Rotterdam