Objective
To combat the growing number of antibiotic-resistant bacteria new therapeutic strategies are needed. Our proposal aims to create novel therapeutics that can interfere with the adhesion of pathogenic bacteria to carbohydrate ligands present on target tissues. For many bacteria this event is the first and crucial step that leads to an infection. Since multiple copies of the bacterial receptors are present the optimal strategy is to use multiple copies of the carbohydrate, i. e. multivalency. This strategy can lead to dramatically enhanced binding compared to monovalent interactions. The specific carbohydrates will be synthesised chemically and will be coupled to novel multivalent backbone molecules. The molecules are evaluated in various adhesion assays and their applicability will be evaluated with relevant animal model studies. Our target pathogenic bacteria are H. pylori, E. coli, and S. suis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules carbohydrates
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3584 CA UTRECHT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.