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Mechanism-guided in vitro evolution

Objective

Using a directed evolution approach, the activities of two structurally similar enzymes, alkaline phosphates and arylsulfatase, will be evolved into each other. The detailed mechanistic characterisation of the new enzymes will address questions about the initial stages of an evolutionary process and the nature of catalysis.

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Address
80,Tennis Court Road, 80
CB2 1GA Cambridge
United Kingdom