Skip to main content

Mesodermal stem cells : from basic biology to development of pre-clinical models of tissue replacement and cell therapy.

Objective

This is a research and development project, describing a new biotechnology approach to cell replacement therapy for a number of severe diseases, based on genetically modified mesoderm stem cells.
The research will cover all aspects of the problem, including:
1) isolation of stem cells from different tissues and organs,
2) study of their phenotype and basis biology,
3) design and construction of viral vectors for their genetic modification,
4) development of pre-clinical models of disease correction by genetically-modified stem cell transplantation, and
5) products and protocols for phase I/II clinical application.
The research will be carried out by a partnership of six laboratories in four different European countries, which include a start-up biotechnology company with a strategic interest in tissue engineering and gene therapy. The groups are led by top European scientists who pioneered the field and have the highest qualification.

Call for proposal

Data not available

Coordinator

UNIVERSITY OF ROME "LA SAPIENZA"
Address
Piazzale Aldo Moro 5
00185 Roma
Italy
 

Participants (5)

ERASMUS UNIVERSITEIT ROTTERDAM
Netherlands
Address
Burgemeester Oudlaan 50
1738 Rotterdam
GENERA SPA
Italy
Address
Via Olgettina 58
20132 Milano
 
INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 25
75724 Paris
 
MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH
Italy
Address
Via Eritrea 62
20157 Milano
Medical Research Council (MRC)
United Kingdom
Address
20 Park Crescent
W1N 4AL London