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Engineering of the cellular quality control systems in bacillus subtilis for the production of high value-added proteins

Objective

The Bacillus protein secretion machine contains cellular quality control systems that efficiently remove misfolded or incompletely synthesised proteins. Paradoxically, these quality control systems represent a major problem for the production of heterologous proteins at commercially significant concentrations. The ultimate objective is to develop a set of super-producer strains. Full use will be made of recent advances in genomics (eg.: DNA arrays), proteomics, bioinformatics, directed molecular evolution and information obtained from previous, EU-funded programmes on Bacillus protein secretion, genome sequencing and the systematic gene fuction analysis. The proposal includes the potential to 'spin-off a research-based biotechnology SME or trust company.

Call for proposal

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Coordinator

NETHERLANDS RESEARCH SCHOOL FOR ASTRONOMY - LEGALLY REPRESENTED BY UNIVERSITY OF GRONINGEN
EU contribution
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Address
5,Broerstraat 5
9712 CP GRONINGEN
Netherlands

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Total cost
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Participants (9)