Obiettivo
The Bacillus protein secretion machine contains cellular quality control systems that efficiently remove misfolded or incompletely synthesised proteins. Paradoxically, these quality control systems represent a major problem for the production of heterologous proteins at commercially significant concentrations. The ultimate objective is to develop a set of super-producer strains. Full use will be made of recent advances in genomics (eg.: DNA arrays), proteomics, bioinformatics, directed molecular evolution and information obtained from previous, EU-funded programmes on Bacillus protein secretion, genome sequencing and the systematic gene fuction analysis. The proposal includes the potential to 'spin-off a research-based biotechnology SME or trust company.
Campo scientifico
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringcontrol systems
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencesbiological sciencesgeneticsDNA
- natural sciencesbiological sciencesgeneticsgenomes
- natural sciencesbiological sciencesmolecular biologymolecular evolution
Argomento(i)
Invito a presentare proposte
Data not availableMeccanismo di finanziamento
CSC - Cost-sharing contractsCoordinatore
9712 CP GRONINGEN
Paesi Bassi