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Engineering of the cellular quality control systems in bacillus subtilis for the production of high value-added proteins

Obiettivo

The Bacillus protein secretion machine contains cellular quality control systems that efficiently remove misfolded or incompletely synthesised proteins. Paradoxically, these quality control systems represent a major problem for the production of heterologous proteins at commercially significant concentrations. The ultimate objective is to develop a set of super-producer strains. Full use will be made of recent advances in genomics (eg.: DNA arrays), proteomics, bioinformatics, directed molecular evolution and information obtained from previous, EU-funded programmes on Bacillus protein secretion, genome sequencing and the systematic gene fuction analysis. The proposal includes the potential to 'spin-off a research-based biotechnology SME or trust company.

Invito a presentare proposte

Data not available

Meccanismo di finanziamento

CSC - Cost-sharing contracts

Coordinatore

NETHERLANDS RESEARCH SCHOOL FOR ASTRONOMY - LEGALLY REPRESENTED BY UNIVERSITY OF GRONINGEN
Indirizzo
5,Broerstraat 5
9712 CP Groningen
Paesi Bassi
 

Partecipanti (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Francia
Indirizzo
Place Jussieu 2, Tour 43
75251 Paris
 
FORSCHUNGSZENTRUM JUELICH GMBH
Germania
Indirizzo
Leo-brand-strasse
52425 Juelich
GENENCOR INTERNATIONAL BV
Paesi Bassi
Indirizzo
1,Archimedesweg 30
2333 Leiden
 
NATIONAL PUBLIC HEALTH INSTITUTE
Finlandia
Indirizzo
Mannerheimintie 166
Helsinki
 
NOVOZYMES A/S
Danimarca
Indirizzo
Kroegshoejvej 36
2880 Bagsvaerd
UNIVERSITAET BAYREUTH
Germania
Indirizzo
Universitaetsstrasse 30
95447 Bayreuth
 
UNIVERSITY OF GREIFSWALD
Germania
Indirizzo
F.-l.-jahnstrasse 15
17487 Greifswald
 
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Indirizzo

NE1 7RU Newcastle Upon Tyne
 
UNIVERSITÉ DE PARIS VII DENIS DIDEROT
Francia
Indirizzo
Place De Jussieu 2 Tour 43
75251 Paris