Objective
The Bacillus protein secretion machine contains cellular quality control systems that efficiently remove misfolded or incompletely synthesised proteins. Paradoxically, these quality control systems represent a major problem for the production of heterologous proteins at commercially significant concentrations. The ultimate objective is to develop a set of super-producer strains. Full use will be made of recent advances in genomics (eg.: DNA arrays), proteomics, bioinformatics, directed molecular evolution and information obtained from previous, EU-funded programmes on Bacillus protein secretion, genome sequencing and the systematic gene fuction analysis. The proposal includes the potential to 'spin-off a research-based biotechnology SME or trust company.
Fields of science
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringcontrol systems
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencesbiological sciencesgeneticsDNA
- natural sciencesbiological sciencesgeneticsgenomes
- natural sciencesbiological sciencesmolecular biologymolecular evolution
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
9712 CP Groningen
Netherlands
See on map
Participants (9)
75251 Paris
See on map
52425 Juelich
See on map
2333 Leiden
See on map
Helsinki
See on map
2880 Bagsvaerd
See on map
95447 Bayreuth
See on map
17487 Greifswald
See on map
NE1 7RU Newcastle Upon Tyne
See on map
75251 Paris
See on map