Objective Gene transfer into the haematopoietic system is a promising therapy for several inherited (immunodeficiencys, liposome storage disorders, haemophilias) or acquired human diseases (AIDS, cancer). Yet the genetic modification of human haematopoietic stem cells (HSC) to provide a lifelong supply of corrected progeny remains the most daunting challenge to the success of this endeavour, because HSC are mostly quiescent and hence difficult to transduce. A major breakthrough has been obtained through the creation of lentiviral vectors, which can mediate the efficient integration and long-term expression of transgenes into no dividing cells, including HSC. This project aims at exploiting the tremendous potential of lentiviral vectors for gene transfer into HSC, in order to bring this new technology from bench to bedside for the therapy of human disease, and to exact its value for the competitiveness of the EU biomedical industry. Fields of science medical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF TORINO EU contribution No data Address Via Giuseppe Verdi 8 10124 TORINO (TURIN) Italy See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO Italy EU contribution No data Address Via Olgettina 58 20132 MILANO See on map Total cost No data GENETHON III France EU contribution No data Address RUE DE L'INTERNATIONALE 1BIS 91002 EVRY See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address 46,Allée d'Italie 46 ADR 5 - Rhône-Alpes, Auvergne, B 69364 Lyon See on map Total cost No data MOLECULAR MEDICINE SPA Italy EU contribution No data Address VIA OLGETTINA 58 MILANO See on map Links Website Opens in new window Total cost No data UNIVERSITY OF GENEVA Switzerland EU contribution No data Address 24,Rue General Dufour 24 1211 GENEVE See on map Total cost No data
