Objective
Apoptosis is the genetically determined form of controlled cellular elimination that accounts for most of the cell death that takes place in-vivo. It is also the primary mechanism of cell death during the in-vitro cultivation of mammalian cell lines used in the production of biopharmaceuticals. In recent years, lab scale studies have indicated that the suppression of the apoptotic pathway during the synthesis of these high value products can substantially increase the productivity of the culture process. In the demonstration proposed here, we will develop new cell lines that incorporate anti-apoptosis genes and will demonstrate the impact of this strategy on the efficiency of state of the art industrial-scale biopharmaceucical production processes, and then make them available to the biotechnology industry.
- Assessment of transfectants over-expressing Bcl-2 protein, generated in previous programme, in a state-of-the-art biopharmaceutical manufacturing process was completed;
- Bank of NS0 clones expressing different levels of Bcl-2 protein secured and selected clones characterised.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology mechanical engineering manufacturing engineering
- natural sciences biological sciences biochemistry biomolecules proteins
- social sciences economics and business economics production economics productivity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.