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Cellular production of human recombinant collagens, gelatins, laminins and growth factors and their use in vascular grafts and other applications

Objective

Collagens and laminas have crucial roles in the extra cellular matrix. Collagens have many applications in medicine, cosmetics and commodity products. Collagens presently used for such applications are derived from animal tissues. We will develop efficient recombinant production applicable to any given collagen type, and test the efficacy of the produced human collagens in several applications. We will also develop man-made basement membranes composed of suitable combinations of collagens; laminas and growth regulators endogenously present in these therapeutically important specialized matrices, and test their use in improving the endothelialization of vascular grafts. Furthermore, we will develop recombinant production of gelatine used in numerous applications.

Funding Scheme

CSC - Cost-sharing contracts
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Coordinator

UNIVERSITY OF OULU
Address
Pentti Kaiterankatu 1
90014 Oulu
Finland

Participants (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
7,Passage Du Vercors 7
69367 Lyon
FIBROGEN EUROPE OY
Finland
Address
Kiviharjuntie 11
90220 Oulu
KAROLINSKA INSTITUTE
Sweden
Address
9,Doktorsringen 9 A
171 77 Stockholm
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Am Klopferspitz 18 A
82152 Martinsried
UNIVERSITY OF HELSINKI
Finland
Address
3,Haartmaninkatu 3
00014 Helsinki