Objective
The aim is to identify and exploit viral modifiers of apoptosis and cytokine responses (particularly Toners) as a potential source of novel health care pharmaceuticals for manipulation of immune responses and treatment of certain diseases. Such virus genes will be identified by nucleotide sequence and functional analysis of cloned viral Orbs and coda libraries of three large DNA viruses (African swine fever, Extremely and Mouse herpes). Possible human homologue of novel sequences will be characterised. The cellular targets of these viral evasion genes and their impact on apoptosis and virus pathogenesis will be determined. Determination of minimal active sequences will permit the development of low molecular weight peptide drugs, starting with the calcineurin phosphates inhibitor A238L gene of ASFV.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health sciencesbasic medicineimmunology
- natural sciencesmathematicspure mathematicsmathematical analysisfunctional analysis
- medical and health scienceshealth sciencesinfectious diseasesDNA viruses
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
2780-156 OEIRAS
Portugal