Objective
The Crenarchaeotes constitute a kingdom of the Archaea that contains a very diverse range of microorganisms many of which are extreme- or hyperthermophiles. They differ extensively genetically and biochemically from Bacteria and Eukaryotes. Sulfolobus is the best studied of these organisms and most of ground-breaking work on this organism has been done in Europe. The purpose of this project is to exploit this European advantage and to screen for novel enzyme activities both at the genomic level and in an extensive and unique European collection of thermophilic Crenarchaeotes. Moreover, we will develop and refine vector systems for expressing these proteins in a range of Bacterial and Eukaryotic hosts by modifying the Archaeal genetic signals. In particular, we will develop, for the first time, a vector-host system for expressing Crenarchaeal enzymes in Sulfolobus on a large scale.
Fields of science
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
1350 Koebenhavn K/copenhaegen
Denmark
See on map
Participants (8)
82347 Bernried
See on map
SP4 0JG Salisbury
See on map
2880 Bagsvaerd
See on map
2800 Lyngby
See on map
80134 Napoli
See on map
64287 Darmstadt
See on map
75105 Uppsala
See on map
6700 EV Wageningen
See on map