Objective Hsp70 is the central component of a multi-chaperone machine involved in many essential cellular processes and in the response of cells to proteotoxic stresses (e.g. heat shock). Furthermore, Hsp70 is a potent anti-apoptotic protein that can enhance transformation and the tumorigenic potential of cells. This proposal aims to obtain detailed knowledge of the function of the Hsp70 machine and its regulation by co-chaperones. This knowledge will be used to gain insight in its exact role in disease pathogenesis with special emphasis on cancer. The results are expected to reveal new possibilities for therapeutic interventions. The knowledge obtained will, furthermore, be exploited to improve the industrial use of mammalian cells as protein factories by attacking major problems in the large- scale production of therapeutic proteins in mammalian cells, i.e. increased apoptosis, sensitivity to temperature shifts, and incomplete protein folding. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein foldingmedical and health sciencesclinical medicineoncology Keywords Nanotechnology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator NETHERLANDS RESEARCH SCHOOL FOR ASTRONOMY - LEGALLY REPRESENTED BY UNIVERSITY OF GRONINGEN Address 5,boemsingel 1 9713 BZ Groningen Netherlands See on map EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all DANISH CANCER SOCIETY Denmark EU contribution € 0,00 Address 49,strandboulevarden 49 2100 Koepenhagen See on map INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY Poland EU contribution € 0,00 Address Ks. trojdena 4 Warszawa See on map MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution € 0,00 Address Am klopferspitz 18 a 82152 Martinsried See on map NOVO-NORDISK A/S Denmark EU contribution € 0,00 Address 1,novo allt, 6b3 2880 Bagsvaerd See on map UNIVERSITY COLLEGE LONDON United Kingdom EU contribution € 0,00 Address Bath street 11-43 EC1V 9EL London See on map UNIVERSITY OF IOANNINA Greece EU contribution € 0,00 Address 1,salamaga 1 45110 Ioannina See on map
