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Exploiting the hsp70 chaperone machine for novel therapeutic strategies in human diseases and for the engineering of productive cellular biomolecular factories

Objective

Hsp70 is the central component of a multi-chaperone machine involved in many essential cellular processes and in the response of cells to proteotoxic stresses (e.g. heat shock). Furthermore, Hsp70 is a potent anti-apoptotic protein that can enhance transformation and the tumorigenic potential of cells. This proposal aims to obtain detailed knowledge of the function of the Hsp70 machine and its regulation by co-chaperones. This knowledge will be used to gain insight in its exact role in disease pathogenesis with special emphasis on cancer. The results are expected to reveal new possibilities for therapeutic interventions. The knowledge obtained will, furthermore, be exploited to improve the industrial use of mammalian cells as protein factories by attacking major problems in the large- scale production of therapeutic proteins in mammalian cells, i.e. increased apoptosis, sensitivity to temperature shifts, and incomplete protein folding.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NETHERLANDS RESEARCH SCHOOL FOR ASTRONOMY - LEGALLY REPRESENTED BY UNIVERSITY OF GRONINGEN
Address
5,Boemsingel 1
9713 BZ Groningen
Netherlands

Participants (6)

DANISH CANCER SOCIETY
Denmark
Address
49,Strandboulevarden 49
2100 Koepenhagen
INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY
Poland
Address
Ks. Trojdena 4
Warszawa
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Am Klopferspitz 18 A
82152 Martinsried
NOVO-NORDISK A/S
Denmark
Address
1,Novo Allt, 6B3
2880 Bagsvaerd
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Bath Street 11-43
EC1V 9EL London
UNIVERSITY OF IOANNINA
Greece
Address
1,Salamaga 1
45110 Ioannina