Characterization of glycoslation structures of pharmaceutical proteins produced in plants with dna-microarrays and glycoprotein fingerprinting

Objective

The effects of glycosylation of proteins are gaining more and more importance, e.g. requirements. Numerous production techniques of recombinant proteins as drugs are developed at the moment. The quality for the pharmaceutical effect of those drugs is often dependent on the glycosylation status. Therefore a constantglycosylation is most crucial and needs to be monitored. Healthcare Technologies has developed a system and reliable method of glycosylation fingerprinting. Phytowelt is working on the production of recombinant proteins in plants and normal profiling by coda micro arrays. To access the utility of this production system both companies aim to evaluate the compatibility of their diagnostic systems to develop a safe and cost efficient production method combined with a method to monitor product quality and reliability in a cost efficient way.

Programme(s)

FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

1.1.1.-3. - Key action The "Cell factory"

Funding Scheme

EAW - Exploratory awards

Coordinator

PHYTOWELT GMBH

Address

Kölsumer Weg 33
41334 Nettetal
Germany

Participants (1)

HEALTHCARE TECHNOLOGIES LTD

Israel