Objective
There is an urgent need for the discovery of novel antibacterial compounds to combat deadly new multi-drug resistant strains. Our targets are the bacterial apoptotic systems (Bass). Since they differ substantially in bacteria and eucalypts the Bass and their checkpoint elements constitute an attractive and unexplored family of targets for development of new antibiotics, which is the essence of our proposal. The novelty of this approach lies in the development of assays to highlight the deregulation of the Bass. Our objective is to engineer bacterial strains for in vivo screening and in vitro biochemical detection methods for the identification of novel compounds that deregulate the Bass. High-throughput screening (HTS) and detailed structure-activity knowledge of the Bass will be used for synthetic modifications to enhance the specificity of targeting.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance
You need to log in or register to use this function
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
MADRID
Spain