This project is aimed at developing and applying novel methodologies for the exploitation of Baeyer-Villiger monooxygenase based biocatalysts. In a framework 4 programme (BIO4-CT98-0267) we have successfully shown that the use of these biocatalysts is possible on a laboratory and pilot plant scale for the synthesis of optically pure lactones as useful synthetic reagents for a range of industrial products. However scale-up beyond this for industrial exploitation will require addressing a number of key bottlenecks. In this project we aim to address these bottlenecks with the objective of devising safe, efficient and environmentally compatible processes suitable for large-scale operation and to demonstrate this with the industrial partner at 50 and 1000 L scale. Additionally a systematic scale-up methodology will be demonstrated.
Funding SchemeDEM - Demonstration contracts