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Whole-cell baeyer-villiger monooxygenase biocatalysts: methodologies for exploitation

Objective

This project is aimed at developing and applying novel methodologies for the exploitation of Baeyer-Villiger monooxygenase based biocatalysts. In a framework 4 programme (BIO4-CT98-0267) we have successfully shown that the use of these biocatalysts is possible on a laboratory and pilot plant scale for the synthesis of optically pure lactones as useful synthetic reagents for a range of industrial products. However scale-up beyond this for industrial exploitation will require addressing a number of key bottlenecks. In this project we aim to address these bottlenecks with the objective of devising safe, efficient and environmentally compatible processes suitable for large-scale operation and to demonstrate this with the industrial partner at 50 and 1000 L scale. Additionally a systematic scale-up methodology will be demonstrated.

Coordinator

UNIVERSITY COLLEGE LONDON
Address
Torrington Place
WC1E 7JE London
United Kingdom

Participants (4)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Avenue De Luminy 163, Case 901
13288 Marseille
FLUKA PRODUCTION GMBH
Switzerland
Address
Industriestrasse 25
9470 Haag
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Via Mario Bianco 9
20131 Milano
UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II
France
Address
Avenue De Luminy 163
13288 Marseille