Objective
Our goal is to establish a successful gene therapy protocol for autonomic dominant polycentric kidney disease (ADPKD), which is the most frequent renal genetic disease (prevalence 1:1,000). 50% of ADPKD patients require renal replacement therapy by the age of 60, resulting in health care costs of 500 million Euro/year. No causal therapy for ADPKD is known. We will pursue a gene therapy strategy by establishing adequate knockout animal models, by elucidating the role of genes involved in relevant pathogenesis mechanisms and by identifying genetic modifiers affecting the severity of ADPKD. Our work will not only advance the basic knowledge on ADPKD, but it will also yield a number of candidates for gene therapy. Meanwhile, efforts will be devoted to optimising existing kidney gene transfer methods by novel delivery strategies and vectors. Finally, gene therapy experiments in animal models will set the basis for further studies in humans.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences clinical medicine nephrology kidney diseases
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69117 HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.