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Content archived on 2024-06-17

Cellular production of wnts, secreted growth and differentiation factors and their use as coordinators of organ specific stem cells

Objective

Wants encode secreted signals that regulate growth and cellular differentiation of various stem cells during embryonic development. No useful systems are available to express the Wants in their biologically active form and to maintain the stem cells undifferentiated in vitro. We will develop efficient recombinant production applicable to any given Want. The biological activity of the produced Wants will be tested in vitro cellular readout systems and in early Venous embryo. The consortium members have identified that Wants are important maintenance factors of stem cells in many different organ system. The Wants, their receptors and signal transudation components will be screened in these systems. The biological activity of the recombinant Wants will be tested in their capacity to keep the cells pluripotent in vitro and if they play a role in driving cells to specific cell lineages.

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Topic(s)

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Call for proposal

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Funding Scheme

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Coordinator

UNIVERSITY OF OULU
EU contribution
No data
Address
Linnanmaa
90014 OULU
Finland

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Total cost

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Participants (4)

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