Objective
Mortality of acute liver failure is high, an alternative to transplantation is needed and hepatic assist systems taking over the complex liver function are still in the experimental phase. Two promising European bio artificial liver (BAL) systems have been tested with porcine cells. Large clinical use of Balls (like renal dialysis for renal patients) becomes possible when safe, functional cells can be cultivated in large numbers. We aim to develop an effective safe BAL with reversibly immortalised human hepatocytes. This will be achieved by development of reversibly immortalised cell lines, in vitro safety and functionality tests of the cell lines and 1 existing cell line, testing favourable cell lines in the Balls, cell preservation studies, bioreactor improve, in vivo studies of one or both Balls or a hybrid BAL with the most favourable cell line, phase I clinical trials, founding an SME to cultivate the cells and to load Balls with them.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental biotechnology bioremediation bioreactors
- social sciences sociology demography mortality
- medical and health sciences clinical medicine transplantation
- medical and health sciences clinical medicine nephrology renal dialysis
- medical and health sciences medical biotechnology tissue engineering bioartificial liver
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
projects.no_data
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1100 DD AMSTERDAM
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.