Novel genechip technology for simplified detection of molecularly heterogeneous genetic diseases: detection of cystic fibrosis as a model

Project Information

CF-CHIP

Grant agreement ID: QLK3-CT-2001-01982

Project closed

Start date 1 February 2002

End date 31 January 2005

Funded under

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Total cost € 2 659 545,00

EU contribution € 1 633 300,00

Coordinated by

National Microelectronics Research Center
Ireland

Objective

The objective is to develop and demonstrate a new gene array technology platform for high-throughput diagnosis of CF and CF-related diseases as a model for other genetic diseases. An integrated magnetic sensor-based gene array will be developed comprising novel giant magneto resistance or tunnel magneto resistance sensors for direct magnetic detection of hybridisation of target DNA-tagged magnetic beads. New CF diagnostic assays will be developed based on oligonucleotide or based-based magnetic sensor array detection of qualitative or quantitative changes in RNA products resulting from either mutations in the CFTR gene (splice site mutations) or possible atypical RNA expression patterns from other genes caused by the presence of an abnormal CFTR gene. Screens for known mutations in the CFTR gene caused by Snips in genomic DNA samples from blood using a novel primer-extension based micro array method will also be developed

Fields of science

• natural sciences › biological sciences › genetics › DNA
• natural sciences › biological sciences › genetics › mutation
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors
• natural sciences › biological sciences › genetics › RNA

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-3. - Key action The "Cell factory"

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

National Microelectronics Research Center

• EU contribution: No data
• Address: Prospect row, Lee malting ; 30 ; Ireland
• Total cost: No data

Participants (7)

FUNDAÇAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA

Portugal

• EU contribution: No data
• Address: Campo Grande C8 ; 1749-016 LISBOA
• Total cost: No data

INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES

Portugal

• EU contribution: No data
• Address: Rua Alves Redol 9 ; 1000 LISBOA
• Total cost: No data

INTERUNIVERSITAIR MIKRO-ELEKTRONICA CENTRUM VZW

Belgium

• EU contribution: No data
• Address: 75,Kapeldreef 75 ; 3001 HEVERLEE
• Total cost: No data

MWG-BIOTECH UK LTD

United Kingdom

• EU contribution: No data
• Address: Mill Court, Featherstone Road, Wolverton Mill Sout ; MK12 5RD MILTON KEYNES
• Total cost: No data

NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

Greece

• EU contribution: No data
• Address: Thivon and Levadias str., St Sofia's Children Hosp ; 11527 ATHENS
• Total cost: No data

NATIONAL UNIVERSITY OF IRELAND DUBLIN

Ireland

• EU contribution: No data
• Address: Our Lady's Hospital for Sick Children, Crumlin ; 12 DUBLIN
• Total cost: No data

UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK

Ireland

• EU contribution: No data
• Address: Western Road ; CORK
• Total cost: No data