Scavidin: a fusion gene for the treatment of cancer

Informations projet

SCAVIDIN

N° de convention de subvention: QLK3-CT-2001-02166

Projet clôturé

Date de début 1 Janvier 2002

Date de fin 31 Decembre 2004

Financé au titre de

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Coût total € 1 341 000,00

Contribution de l’UE € 1 072 000,00

Coordonné par

UNIVERSITY OF KUOPIO
Finland

Objectif

The main objective of the proposal is to develop a new target-specific delivery system for the treatment of malignant glioma. For that purpose we have cloned a new fusion gene "Cave-in" which contains intracellular and membrane-spanning domains of scavenger receptor legated to avid in which will form the extra cellular domain of the fusion protein. Cave-in will be transfixed to target tissue with local gene therapy via catheter delivery or during surgical operation with adenovirus or pseudotyped retrovirus technology. Targeted treatment is achieved by binding of biotinylated compounds to Cave-in, which will be only expressed in the transfixed tissue.

Champ scientifique

• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › oncology

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Thème(s)

• 1.1.1.-3. - Key action The "Cell factory"

Appel à propositions

Data not available

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

UNIVERSITY OF KUOPIO

• Contribution de l’UE: Aucune donnée
• Adresse: Savilahdentie 9 ; 1627 KUOPIO ; Finlande
• Coût total: Aucune donnée

Participants (3)

ARK THERAPEUTICS LTD.

Royaume-Uni

• Contribution de l’UE: Aucune donnée
• Adresse: Warren Mews 6 ; W1T 6AR LONDON
• Coût total: Aucune donnée

ISTITUTO EUROPEO DI ONCOLOGIA SRL

Italie

• Contribution de l’UE: Aucune donnée
• Adresse: Via Filodrammatici 8 ; 20121 MILANO
• Coût total: Aucune donnée

UNIVERSITY COLLEGE LONDON

Royaume-Uni

• Contribution de l’UE: Aucune donnée
• Adresse: Mortimer Street The Middlesex Hospital ; W1N 8AA London
• Coût total: Aucune donnée