Objective
Prison diseases such as Creutzfeldt-Jakob disease (CJD) and BSE have caused a major concern in regard to public health. We used a novel approach based on fluorescence correlation spectroscopy to develop a highly sensitive detection method for priors termed SIFT (Scanning for Intensely Fluorescent Targets), which has successfully been applied to CSF samples. Moreover, the labelling ratio of two independent probes can be analysed on a single particle level. By this approach, different types of prison particles associated with different variants of CJD could be distinguished in pilot experiments. Within the project, we want to develop this method into a rapid and sensitive diagnostic test that can be used on a routine basis for diagnosis and strain typing in CJD. In addition, we aim at harmonizing and validating biochemical typing of CJD variants at the European level.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health scienceshealth sciencespublic health
- natural sciencesphysical sciencesopticsspectroscopy
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
81377 MUENCHEN
Germany