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Eukaryotic polyketides in surrogate hosts

Objective

Eucharistic organisms contain genes encoding the biosynthesis of complex compounds often with useful biological properties. Traditional methods for exploiting these compounds have included harvest and extraction of organisms, or fermentation. These methods are ineffective for many organisms. EUKETIDES will innovate by obtaining genes directly from a variety of uncultivable eucalypts using new genetic tools. A range of polypeptide syntheses genes will be isolated and used for production of new biologically active molecules by expression in well-characterised bacteria and yeast. These new biosynthetic genes will be combined with known modifying genes for the directed biosynthesis of small libraries of new compounds, resulting in new technology to produce new drugs. Overall we will exploit new advances in genetics, chemistry and fermentation technology to capitalise on leading EU science for the production of high-value new compounds.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF ICELAND
Address
12,Grensasvegur 12
0108 Reykjavik
Iceland

Participants (7)

ALFRED WEGENER INSTITUTE FOR POLAR AND MARINE RESEARCH
Germany
Address
Am Handelshaven 12
27570 Bremerhaven
GALILAEUS OY
Finland
Address
Kairiskulmantie 10
Kaarina
HANS KNOELL INSTITUTE FOR NATURAL PRODUCTS RESEARCH
Germany
Address
Beutenbergstrasse 11
Jena
TECHNICAL UNIVERSITY OF DENMARK
Denmark
Address
Anker Engelundsvej 1, Building 101
2800 Lyngby
UNIVERSITY OF BRISTOL
United Kingdom
Address
Senate House, Tyndall Avenue
BS8 1TH Bristol, Clifton
UNIVERSITY OF SALZBURG
Austria
Address
Kapitelgasse 5-7
5020 Salzburg
UNIVERSITY OF TURKU
Finland
Address
Kiinamyllynkatu 13
20014 Turku