Skip to main content

Target specific delivery systems for gene therapy based on cell penetrating peptides

Objective

The cell membrane penetrating peptides, Capps, are designed and synthesized recently by the partners, and applied for cellular delivery of oligonucleotides. The aim of the present project is the design, synthesis and testing of novel on-viral modes of efficient target selective transport vectors based on CPPstrategy for delivery of DNA single and double strand cargos and applications ingénue therapy. For that, the mechanisms of cell penetration of Capps will be studied. Specific tissue, cell and sub cellular compartment targeting Capps will be developed for application in gene therapy. The libraries of Capps will besynthesised and tested with combination of iterative approach and high throughput screening. The biological effects of successful oligonucleotide delivery systems will be detected in vitro and in vivo, and used in a high-throughput assay of CPPoptimisation

Call for proposal

Data not available

Coordinator

STOCKHOLM UNIVERSITET
Address
Universitetsvaegen 10
10691 Stockholm
Sweden

See on map

Links

Participants (9)

ASTRAZENECA UK LTD
United Kingdom
Address
Stanhope Gate 15
W1Y 6LN London

See on map

Links
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel-ange 3
75794 Paris

See on map

Links
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
46,rue D' Ulm 46 Ecole Normale Superieure
75230 Paris

See on map

Links
CEPEP AB
Sweden
Address
S. Arrheniusvaegen
10891 Stockholm

See on map

Links
ECOLE NORMALE SUPERIEURE
France
Address
Rue D'ulm 46, Ecole Normale Supérieure
75230 Paris

See on map

Links
ESTONIAN BIOCENTRE
Estonia
Address
Riia St. 23
51010 Tartu

See on map

Links
FORSCHUNGSVERBUND BERLIN E.V.
Germany
Address
Rudower Chaussee 17
12489 Berlin

See on map

Links
Medical Research Council (MRC)
United Kingdom
Address
20 Park Crescent
W1N 4AL London

See on map

Links
UNIVERSITE DE MONTPELLIER II - SCIENCES ET TECHNIQUES DU LANGUEDOC
France
Address
Route De Mende, 1919
34293 Montpellier

See on map

Links