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Target specific delivery systems for gene therapy based on cell penetrating peptides

Objectif

The cell membrane penetrating peptides, Capps, are designed and synthesized recently by the partners, and applied for cellular delivery of oligonucleotides. The aim of the present project is the design, synthesis and testing of novel on-viral modes of efficient target selective transport vectors based on CPPstrategy for delivery of DNA single and double strand cargos and applications ingénue therapy. For that, the mechanisms of cell penetration of Capps will be studied. Specific tissue, cell and sub cellular compartment targeting Capps will be developed for application in gene therapy. The libraries of Capps will besynthesised and tested with combination of iterative approach and high throughput screening. The biological effects of successful oligonucleotide delivery systems will be detected in vitro and in vivo, and used in a high-throughput assay of CPPoptimisation

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

STOCKHOLM UNIVERSITET
Adresse
Universitetsvaegen 10
10691 Stockholm
Suède

Participants (9)

ASTRAZENECA UK LTD
United Kingdom
Adresse
Stanhope Gate 15
W1Y 6LN London
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Adresse
Rue Michel-ange 3
75794 Paris
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Adresse
46,Rue D' Ulm 46 Ecole Normale Superieure
75230 Paris
CEPEP AB
Suède
Adresse
S. Arrheniusvaegen
10891 Stockholm
ECOLE NORMALE SUPERIEURE
France
Adresse
Rue D'ulm 46, Ecole Normale Supérieure
75230 Paris
ESTONIAN BIOCENTRE
Estonie
Adresse
Riia St. 23
51010 Tartu
FORSCHUNGSVERBUND BERLIN E.V.
Allemagne
Adresse
Rudower Chaussee 17
12489 Berlin
Medical Research Council (MRC)
United Kingdom
Adresse
20 Park Crescent
W1N 4AL London
UNIVERSITE DE MONTPELLIER II - SCIENCES ET TECHNIQUES DU LANGUEDOC
France
Adresse
Route De Mende, 1919
34293 Montpellier