Objective Aim of the project is to exploit the experience (of a previous EC-funded study) to investigate mechanisms of immunological modifications induced by allergen- (of Mite and Parietaria pollens) encoding DNA vaccines. Their effects will be directly investigated on APCs and on the effector cells responsible for allergic inflammatory response (namely Th2 and B cells, eosinophils and mastcells). This part of the study will be the prerequisite to design and evaluate novel DNA vaccine formulations (and approaches of pDNA delivery) in terms of their effectiveness to inhibit allergic Th2-mediated responses. These systems will be tested and calibrated in novel animal (mouse) and human (in vitro transfected cells) models. Quick and simple assay systems useful to monitor the efficacy of novel pDNA vaccines and their potential side-effects will be validated in view of a possible application to human allergic disorders. Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF FLORENCE Address Piazza san marco 4 50121 Firenze Italy See on map EU contribution No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all CHIRON S.R.L. Italy EU contribution € 0,00 Address Via fiorentina 1 53100 Siena See on map Links Website Opens in new window Other funding No data DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLIN Germany EU contribution € 0,00 Address Am kleinen wannsee 5 14109 Berlin See on map Other funding No data HLA ET MÉDECINE France EU contribution € 0,00 Address 15,rue de l'ecole de médecine 15 75006 Paris See on map Other funding No data NATIONAL RESEARCH COUNCIL OF ITALY Italy EU contribution € 0,00 Address Piazzale aldo moro 7 00185 Roma See on map Other funding No data University of Edinburgh United Kingdom EU contribution € 0,00 Address Old college south bridge EH1 1HN Edinburgh See on map Other funding No data
