Obiettivo Aim of the project is to exploit the experience (of a previous EC-funded study) to investigate mechanisms of immunological modifications induced by allergen- (of Mite and Parietaria pollens) encoding DNA vaccines. Their effects will be directly investigated on APCs and on the effector cells responsible for allergic inflammatory response (namely Th2 and B cells, eosinophils and mastcells). This part of the study will be the prerequisite to design and evaluate novel DNA vaccine formulations (and approaches of pDNA delivery) in terms of their effectiveness to inhibit allergic Th2-mediated responses. These systems will be tested and calibrated in novel animal (mouse) and human (in vitro transfected cells) models. Quick and simple assay systems useful to monitor the efficacy of novel pDNA vaccines and their potential side-effects will be validated in view of a possible application to human allergic disorders. Campo scientifico natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-3. - Key action The "Cell factory" Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF FLORENCE Contributo UE Nessun dato Indirizzo Piazza San Marco 4 50121 FIRENZE Italia Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CHIRON S.R.L. Italia Contributo UE Nessun dato Indirizzo VIA FIORENTINA 1 53100 SIENA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLIN Germania Contributo UE Nessun dato Indirizzo Am Kleinen Wannsee 5 14109 BERLIN Mostra sulla mappa Costo totale Nessun dato HLA ET MÉDECINE Francia Contributo UE Nessun dato Indirizzo 15,Rue de l'Ecole de Médecine 15 75006 PARIS Mostra sulla mappa Costo totale Nessun dato NATIONAL RESEARCH COUNCIL OF ITALY Italia Contributo UE Nessun dato Indirizzo Piazzale Aldo Moro 7 00185 ROMA Mostra sulla mappa Costo totale Nessun dato University of Edinburgh Regno Unito Contributo UE Nessun dato Indirizzo Old College South Bridge EH1 1HN Edinburgh Mostra sulla mappa Costo totale Nessun dato
