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Allergen-derived DNA vaccines: mechanisms involved in mouse and human models

Objective

Aim of the project is to exploit the experience (of a previous EC-funded study) to investigate mechanisms of immunological modifications induced by allergen- (of Mite and Parietaria pollens) encoding DNA vaccines. Their effects will be directly investigated on APCs and on the effector cells responsible for allergic inflammatory response (namely Th2 and B cells, eosinophils and mastcells). This part of the study will be the prerequisite to design and evaluate novel DNA vaccine formulations (and approaches of pDNA delivery) in terms of their effectiveness to inhibit allergic Th2-mediated responses. These systems will be tested and calibrated in novel animal (mouse) and human (in vitro transfected cells) models. Quick and simple assay systems useful to monitor the efficacy of novel pDNA vaccines and their potential side-effects will be validated in view of a possible application to human allergic disorders.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF FLORENCE
Address
Piazza San Marco 4
50121 Firenze
Italy

Participants (5)

CHIRON S.R.L.
Italy
Address
Via Fiorentina 1
53100 Siena
DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLIN
Germany
Address
Am Kleinen Wannsee 5
14109 Berlin
HLA ET MÉDECINE
France
Address
15,Rue De L'ecole De Médecine 15
75006 Paris
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Piazzale Aldo Moro 7
00185 Roma
University of Edinburgh
United Kingdom
Address
Old College South Bridge
EH1 1HN Edinburgh