Objective Inhibitors of metalloproteinases have shown a high therapeutic potency in preliminary clinical trials. However, unacceptable side-effects are associated, which are relative to recently discovered ADAMS and "non classical" effects of MMPs. This project aims at defining the best MMP inhibition profiles for cancer therapy by1) a comprehensive assessment of metalloprateinase activities and functions at both physiological and tumour progression level, i.e. by using first inhibition inhibitors as probe;2) designing new metalloproteinase inhibitors on the basis of inhibitor-enzyme complex 3-D structures and on the biological activities to be tackled;3) assessing the benefit of combining MMP inhibitors with serine proteases inhibitors designed on a similar basis. Fields of science medical and health sciencesclinical medicineoncology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITE DE LIEGE*ULG Address Place du 20 aout 7 4000 Liege Belgium See on map EU contribution € 0,00 Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution € 0,00 Address Rue laurent fries 1 67404 Illkirch graffenstaden See on map COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution € 0,00 Address Batiment 152, cea/saclay 91191 Gif sur yvette See on map COPENHAGEN UNIVERSITY HOSPITAL Denmark EU contribution € 0,00 Address Stransboulevarden 49 2100 Koepenhagen See on map GERMAN CANCER RESEARCH CENTER Germany EU contribution € 0,00 Address Im neuenheimer feld 280 69120 Heidelberg See on map INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 0,00 Address Rue laurent fries 1 67404 Illkirch graffenstaden See on map MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution € 0,00 Address Am klopferspitz 18 a 82152 Martinsried See on map NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS Greece EU contribution € 0,00 Address Panepistimiopolis zographou 15771 Zographos, athens See on map THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 0,00 Address Trinity lane, the old schools, CB2 1TN Cambridge See on map UNIVERSIDAD DE OVIEDO Spain EU contribution € 0,00 Address San francisco 1-5 33003 Oviedo See on map
