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Profiling metalloprotease inhibition for tumour therapy

Cel

Inhibitors of metalloproteinases have shown a high therapeutic potency in preliminary clinical trials. However, unacceptable side-effects are associated, which are relative to recently discovered ADAMS and "non classical" effects of MMPs. This project aims at defining the best MMP inhibition profiles for cancer therapy by
1) a comprehensive assessment of metalloprateinase activities and functions at both physiological and tumour progression level, i.e. by using first inhibition inhibitors as probe;
2) designing new metalloproteinase inhibitors on the basis of inhibitor-enzyme complex 3-D structures and on the biological activities to be tackled;
3) assessing the benefit of combining MMP inhibitors with serine proteases inhibitors designed on a similar basis.

Zaproszenie do składania wniosków

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System finansowania

CSC - Cost-sharing contracts

Koordynator

UNIVERSITE DE LIEGE*ULG
Wkład UE
Brak danych
Adres
PLACE DU 20 AOUT 7
4000 LIEGE
Belgia

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Koszt całkowity
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Uczestnicy (9)