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Content archived on 2024-05-21

Anchored cAMP signalling - implications for treatment of human disease

Objective

Signalling pathways and networks involving the signal compound cAMP are involved in major chronic diseases within the European community such as HIV, cancer, diabetes type II, cardiovascular disease, and genetic diseases such as diabetes incipidus and muscular dystrophies. However, no systematic approach has explored the therapeutic potential in targeting the cAMP signal pathway in conditions such as listed above with a dysregulated cAMP signal pathway. The focus of the research in the present proposal is to devise and test of therapeutic strategies based on understanding function of components of signalling networks involving the signal compound cAMP, the down-stream effectors, interaction with targeting molecules, and substrates. Specifically, work will be aimed at solving highly competitive and major tasks by joint effort leading to in vivo proof of principle experiments and drug development.

Call for proposal

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Coordinator

UNIVERSITY OF OSLO
EU contribution
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Address
Sognvannsveien 9
0317 OSLO
Norway

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Total cost
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Participants (9)