Objective The objective of the proposal is to develop an assay in ES cells to study Arcadia protein function and Nodal-Nodal interaction. Nodal/Nodal signalling will be used to examine the in vitro differentiation of ES cells into germ layer specific precursors and to characterize the pathway of organiser/me endoderm induction. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator MEDICAL RESEARCH COUNCIL EU contribution No data Address Du Cane Road, Hammersmith Hospital W12 0NN LONDON United Kingdom See on map Total cost No data